Meta analysis of effect of vitamin d supplementation on diastolic blood pressure, update meta analysis of randomized controlled trials of the effect of vitamin d on blood pressure in the general population. Data about anticoagulation in pulmonary arterial hypertension pah patients are inconsistent. Hypertension was defined as a mean sbp of at least 140 mmhg or a dbp of at least 90 mmhg, or use of antihypertensive medication. We searched the pubmed, cochrane, embase, and proquest databases using a combination of mesh and free text, from the inception of these databases to 20 january 2020, with no language restrictions. In 2012, we studied 2,456 men and women free of prevalent hypertension, age 21 to 67 at baseline. The prevalence of hypertension among children varied significantly when measured by different devices.
The results persisted in most subgroup and sensitivity analyses. Dec 28, 2018 a meta analysis was performed if at least three studies used the same definition of frailty and a dichotomous definition of hypertension. The burden of hypertension in subsaharan africa has been increasing over the past few decades. Franco, c emanuele di angelantonio, a and dorairaj prabhakaran d.
The highly neglected burden of resistant hypertension in. Metaanalysis of hypertension trials in diabetic patients. Risk of hypertension in cancer patients treated with abiraterone. Risk of bias, publication bias, and overall certainty of evidence the studies overall had moderate to good methodological quality table 2. Cardiovascular risk cvd are the leading cause of mortality worldwide, accounting for 30% of all global deaths1. Effects of hypertension, diabetes and coronary heart. Eva munoz aguilera, jean suvan, jacopo buti, marta czesnikiewiczguzik, aline barbosa ribeiro, marco orlandi, tomasz j guzik, aroon d hingorani, jose nart, francesco daiuto, periodontitis is associated with hypertension. Effects of hypertension, diabetes and coronary heart disease. Six studies 1, 48 reported that hypertension, diabetes, and copd, five. The q test and i2 statistic were used to examine betweenstudy heterogeneity. Hypertension characteristics and quality of studies six studies, including 324 severe group cases and 1234 a total of 1558 samples from 6 retrospective studies were enrolled in this metaanalysis 1, 48. An overview of the metaanalyses of the hypertension treatment.
Department of health and human services 2000, the leading cause of death worldwide world health organization 2009. Metaregression analyses showed relative risk reductions. The burden and high prevalence of hypertension in pakistani. The specific contribution of abiraterone to hypertension has not been defined.
We then used these data to perform ipd metaanalysis to evaluate the effect of selfmonitoring on bp levels and in the control of hypertension using 1 year of followup as our primary end point. Mar 20, 2017 overall analysis of hypertension and breast cancer risk. Metaanalysis of hypertension trials in diabetic patients marco pahor, bruce m. For example, when analysis was restricted to studies. Blood pressure, hypertension and the risk of sudden cardiac death. Setting, participants and measures studies providing information on the association between frailty and hypertension in adult persons, regardless of the study setting, study design or definition of. Blood pressure lowering for prevention of cardiovascular disease. The results of metaanalysis will be relatively accurate. Relevant studies were identified by a search of pubmed, embase, china national knowledge infrastructure, wanfang, the chinese biomedical literature, and weipu database until december 2015. In subgroup analysis, bevacizumab dose, sample size and hypertension grade of controls may account for the presence of significant heterogeneity based on significant differences in stratified relative risk table 2.
Haemodynamic elevated blood pressure bp and metabolic hyperlipidaemia and. Preeclampsia is a serious pregnancyrelated disease which may lead to adverse health effects to the mother and fetus. Cumulative meta analysis displaying temporal trends in idiopathic pulmonary arterial hypertension pah patients. Is anticoagulation beneficial in pulmonary arterial hypertension. Risk of hypertension in cancer patients treated with. Table 2 shows the subgroup analyses of summary wmds in sbp and dbp. Methods we conducted a search in pubmed, embase, web of science and global index medicus to identify articles published from inception to 30. Objectives the study sought to determine the link between vitamin d concentrations and incident hypertension in prospective study and metaanalysis. Increased risk of highgrade hypertension with bevacizumab. The recent publication of a new metaanalysis of 14 randomized trials of antihypertensive drug therapy in the lancet has heightened the debate regarding the benefits of treatment of hypertension.
Effects of probiotics on patients with hypertension. Association between hypertension and deep vein thrombosis. The objective of this study was to examine the impact of adjunctive oral anticoagulants in patients with pah through metaanalysis, and to further assess whether response differs by pah subtype. The recent publication of a new meta analysis of 14 randomized trials of antihypertensive drug therapy in the lancet has heightened the debate regarding the benefits of treatment of hypertension. Hypertension is the primary and most common risk factor for heart disease, stroke, and renal disease and has been identified as the leading cause of mortality and third cause of disabilityadjusted life years worldwide. Besides many publications on the association of red cell distribution width rdw and preeclampsia, there has been no published metaanalysis. Renal denervation and blood pressure reduction in resistant hypertension. Metaanalysis now offers the opportunity to critically evaluate and statistically combine results of comparable studies or trials. As for the results of study, it is a positive conclusion, our meta analysis shows that berberine has a therapeutic effect on type 2 dm, hyperlipidemia and hypertension and has less sideeffects. Metaanalysis of implementation strategies for blood pressure control. The recent publication of a new metaanalysis of 14 randomized trials of antihypertensive drug therapy in the lancet has heightened the debate regarding the.
Pubmed and embase databases were searched to identify all related prospective cohort studies. Metaanalysis renal denervation and blood pressure reduction. However, each metaanalysis has the limitations of methodology or research object. Data sources we searched pubmed, cochrane library databases, embase and the science citation index expanded through december 2015. The dashed line indicates the pooled restricted cubic spline model, and the solid lines indicate the 95% cis of the pooled curve. Its major purposes are to increase the numbers of observations and the statistical power, and to improve the estimates of the effect size of an intervention or an association. The association between hypertension and dvt after orthopedic surgery was. This meta analysis is to analyze the correlation between hypertension, diabetes, coronary heart disease and covid19 disease severity. We therefore conducted this metaanalysis to determine the relationship between risk of cataract and hypertension. We searched the pubmed, cochrane, embase, and proquest databases using a combination of mesh and free text, from the inception of these databases to 20 january 2020, with no. Covid19 patients with chronic diseases such as hypertension, diabetes and coronary heart diseases is more likely to worsen, but with mixed results for covid19 severity. Blood pressure lowering for prevention of cardiovascular.
Only randomised controlled trials rcts were included. The interpretation and reporting of these data are the responsibility of the authors and in no way should be seen as an official policy of or interpretation by the national institutes of health nih. A metaanalysis article pdf available in plos one 912. However, a large proportion of the population with hypertension remains undiagnosed, untreated, or inadequately treated, contributing to the rising burden of cardiovascular disease in the region.
Hypertension has been recognized as a global health concern for developing countries and is scarcely described in many of these countries. We then used these data to perform ipd meta analysis to evaluate the effect of selfmonitoring on bp levels and in the control of hypertension using 1 year of followup as our primary end point. Metaanalysis allows you to determine the overall effect on the basis of the studies effects. How does exercise treatment compare with antihypertensive. Department of preventive medicine, stony brook university medical center, stony brook, new york, usa. Blood and urine cadmium, blood pressure, and hypertension. Jun 12, 2019 for the primary analysis using only prospective studies, we conducted 30 meta analyses of hypertension and 16 different cancers, and 29 meta analyses between sbp or dbp and 11 cancers. Methods the study was embedded in the kailuan study, a populationbased cohort of adults that contains underground miners. The prevalence of hypertension is markedly higher in the urban population compared to the rural population, but the prevalence in the rural population is also a matter of concern with almost.
Meta analysis of hypertension trials in diabetic patients marco pahor, bruce m. Stress reduction programs in patients with elevated blood. As for the results of study, it is a positive conclusion, our metaanalysis shows that berberine has a therapeutic effect on type 2 dm, hyperlipidemia and hypertension and has less sideeffects. Cohen reports grants from the nih, national heart, lung, and blood institute, during the conduct of. Background covid19 patients with chronic diseases such as hypertension, diabetes and coronary heart diseases is more likely to worsen, but with mixed results for covid19 severity.
Increased risk of highgrade hypertension with bevacizumab in. We identified 123 studies with 6 815 participants for the tabular metaanalysis. Objectives the study sought to determine the link between vitamin d concentrations and incident hypertension in prospective study and meta analysis. Advantages and disadvantages of the metaanalysis approach. Metaanalysis of the effect and safety of berberine in the. Globally, hypertension is the leading cause of cardiovascular disease and cardiovascular mortality, with more than 1 billion adults affected worldwide and 10. Bevacizumab significantly increased the risk of hypertension in cancer patients, as shown by our metaanalysis based on seven randomizedcontrolled clinical trials rcts. An overview of the metaanalyses of the hypertension. Six studies 1, 48 reported that hypertension, diabetes, and. Many epidemiologic studies indicated that hypertension might play an important role in the development of cataract, while others not.
Therefore, our metaanalysis including western and korean studies may underestimate the effect of acupuncture for hypertension. The clinical outcomes and effectiveness of mhealth. Therefore, our meta analysis including western and korean studies may underestimate the effect of acupuncture for hypertension. Overall analysis of hypertension and breast cancer risk. Research paper does comorbidity increase the risk of. Association between periodontitis and arterial hypertension. Available data from pubmed, web of science, china national. Metaregression analyses showed relative risk reductions proportional to the magnitude of the blood pressure reductions achieved. Association between blood pressure and risk of cancer.
Methods study design and search strategydata source a systematic metaanalysis was done using published and unpublished articles on prevalence of hypertension in ethiopia. The etiology of essential htn, however, is unknown carretero and oparil 2000, but cadmium exposure has been inconsistently associated with blood pressure bp. Metaanalysis is used to evaluate the effect that is described by a number of publications. The inverse variance method with a randomeffects model was used to pool the risk estimates from the individual studies. While the present metaanalysis should not be considered conclusive, it seems beneficial to prefer an ace inhibitor as a firstline agent when treating hypertension in diabetic patients.
A second sensitivity analysis was performed by comparing the metaanalysis from all 17 studies with a metaanalysis of the studies which focused on cardiac related health issues but did not have hypertension as an explicit inclusion criteria, although the majority of the participants had hypertension 19, 20, 2426. This metaanalysis is to analyze the correlation between hypertension, diabetes, coronary heart disease and covid19 disease severity. Available data from pubmed, web of science, china national knowledge. Regional differences in risk and protective factors for hypertension and differences in acupuncture techniques could substantially affect the potential efficacy of acupuncture. The meta analysis table lists the prevalence of hypertension expressed as a percentage, with their 95%ci found in the individual studies included in the meta analysis. Hypertension is one of the major side effects associated with abiraterone in the treatment of advanced prostate cancer. The pooled proportion prevalence with 95%ci is given for the random effects model. Methods available data from pubmed, web of science, china national knowledge infrastructure. However, each meta analysis has the limitations of methodology or research object. Methods there is, as yet, no unanimously accepted strategy for performing a meta analysis but researchers agree that each meta analysis should beconducted like a scientific experiment and begin with a protocol, which clearly states its aim and methodology. A metaanalysis of prospective cohort studies was performed to investigate the effect of pa on hypertension risk. We predefined levels of intensity of cointervention and subgroups of patients for further analysis.
Available data from pubmed, web of science, china national knowledge infrastructure database, wanfang database and vip database, were analyzed using a fixed effects model metaanalysis to derive overall odds ratios or with 95% cis. We aimed to analyze the association between hypertension and deep vein thrombosis dvt after orthopedic surgery. The burden and high prevalence of hypertension in pakistani adolescents. In this metaanalysis, we aim to assess the comparative effectiveness of various implementation strategies on bp reduction in patients with. Jun 16, 2008 our meta analysis suggests that garlic preparations are superior to placebo in reducing blood pressure in individuals with hypertension. Cataract is the major cause of blindness across the world. A metaanalysis was performed if at least three studies used the same definition of frailty and a dichotomous definition of hypertension. A metaanalysis of prevalence studies on hypertension in india from january 2000 to june 2012 reveals a high prevalence of hypertension in the urban 40. Comparators in eligible medication trials included placebo, other medications, doses, or usual care. Pdf blood pressure lowering for prevention of cardiovascular. For the primary analysis using only prospective studies, we conducted 30 metaanalyses of hypertension and 16 different cancers, and 29 metaanalyses between sbp or dbp and 11 cancers. Methods study design and search strategydata source a systematic meta analysis was done using published and unpublished articles on prevalence of hypertension in ethiopia. Methods we conducted a search in pubmed, embase, web of science and global index medicus to identify articles published from inception to 30 september 2017.
Physical activity and risk of hypertension hypertension. Is anticoagulation beneficial in pulmonary arterial. Hypertension htn and smoking are established risk factors for cardiovascular disease u. Objective to assess the clinical and haemodynamic effects of carvedilol for patients with cirrhosis and portal hypertension. Research paper does comorbidity increase the risk of patients. Nonpharmacological treatment options for hypertension have the potential to reduce the risk of cardiovascular disease at a population level. Blood pressure lowering significantly reduces vascular risk across various baseline blood pressure levels and comorbidities. Doctoral program in population health and clinical outcomes research, and.
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